Preventing Delirium 101: Avoid Precipitants

Avoid known delirium precipitants in high-risk patients

Untreated Pain

  • Use opioid alternatives whenever possible

Minimize medications known to precipitate delirium

  • Anticholinergics including first-generation antihistamines and muscle relaxants
  • Benzodiazepines and other sedative-hypnotics
  • Corticosteroids
  • H2-receptor antagonists
  • Meperidine

Avoid unnecessary tethers

  • Foley catheters
  • Tethering telemetry cables
  • Blood pressure cuffs

NOTE

Let’s elaborate:

Mouzopoulos G, et al. J Orthop Traumatol. 2009;10(3):127–133

Pain management in patients with acute pain (eg, hip fracture, rib fracture)

  • Use opioid alternatives
    • Acetaminophen as first line
    • Consider nerve blocks where appropriate
      • Use of fascia iliaca block for patients with hip fracture may ↓ delirium
  • For patients with severe dementia
    • Consider scheduling analgesia (eg, scheduled acetaminophen)
    • Use dementia-specific pain scales
  • For patients who do require opioids, start low and go slow

2019 Updated AGS Beers Criteria®. J Am Geriatr Soc. 2019;67(4):674–694

High-risk medications

  • Table 3 (“Drug-Disease or Drug-Syndrome Interactions That May Exacerbate the Disease or Syndrome”; Delirium section)
  • Table 7 (“Drugs With Strong Anticholinergic Properties”)

References

2019 Updated AGS Beers Criteria®. J Am Geriatr Soc. 2019;67(4):674–694.

Mouzopoulos G, et al. J Orthop Traumatol. 2009;10(3):127–133.