A Guide to Amyloid-Related Imaging Abnormalities in Alzheimer’s Disease

Webinar Recording

Goals

1. Describe the range of symptoms of ARIA that may prompt a patient to seek emergency care and how to differentiate them from more common conditions to appropriately triage these individuals and determine next steps in their management
2. Isolate possible types of ARIA (ARIA-E, ARIA-H) as well as which do and do not require hospital admission/immediate treatment (e.g., corticosteroids) to effectively coordinate variable patient presentations
3.  Identify key areas of interdisciplinary communication that may impact a care team’s ability to successfully triage, diagnose, and/ or treat ARIA and employ corresponding solutions to maximize workflow efficiency and patient outcomes
4. Recognize which medications/treatments that may be administered in the ED are inappropriate or contraindicated in patients prescribed ATTs and strategize management protocols for clinical scenarios in which they would be utilized

Overview

With the first approvals of amyloid-targeting therapies (ATTs) for patients with early Alzheimer’s disease (AD) neurobiology, the way this illness is viewed and managed is facing a paradigm shift. However, while disease-modifying therapies (DMTs) are a long-awaited breakthrough in the treatment of AD, ATTs have also introduced new, class specific adverse effects, amyloid-related imaging abnormalities (ARIA), with which most clinicians, regardless of specialty, have not yet come into contact, creating a host of novel considerations and potential practice changes. This lack of exposure and limited published guidance may be particularly problematic in emergency department (ED) settings which are likely to encounter the most urgent needs of those affected by ARIA.

This live virtual webinar focuses on emergency medicine clinicians’ role in the recognition and acute management of ARIA, including how ARIA may present and what courses of action are needed for different ARIA severities.

Expert Panel

Kevin Biese, MD, MAT
Vice-Chair, Academic Affairs Director
Division Of Geriatric Emergency Medicine Clinical
Associate Professor, Internal Medicine, Division Of Geriatrics
Chapel Hill, NC

Gloria Chiang, MD
Vice Chair, Clinical and Translational Research
Director, Brain Health Imaging Institute
Associate Professor, Neuroradiology, Department of Radiology
Weill Cornell Medicine/NewYork-Presbyterian Hospital
New York, NY

Gayatri Devi, MD, MS, FAAN, FACP
Clinical Professor of Neurology and Psychiatry
Zucker School of Medicine at Hofstra/Northwell
Director, Park Avenue Neurology
New York, NY

Jennifer Sutherland, PharmD, BCEMP
Emergency Medicine Clinical Pharmacy Specialist
PGY2 Emergency Medicine Pharmacy Residency Program Director
Assistant Adjunct Clinical Professor-Division of Practice Management and Clinical Education
UNC Health | UNC Medical Center | UNC Eshelman School of Pharmacy
Chapel Hill, NC

Moderated By

Don Melady

MD

Bio

Dr. Don Melady is an emergency physician at Mount Sinai Hospital in Toronto, Canada and a founding member of the Geriatric Emergency Department Collaborative. He is the author of the website www.geri-EM.com – a CME accredited program for geriatric emergency medicine education – and the chair of the Geriatric EM committee of the International Federation of Emergency Medicine.

Geri-EM.com Geriatric-ED.com Publications